Bom artigo sobre anabolizantes

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Achei um bom artigo sobre anabolizantes, publicado numa revista "peer-reviewed", ou seja, com conteúdo científico legítimo.

Está em inglês no entanto. Acho que vale a pena ler. Baixei o arquivo pdf e fiz o upload no rapidshare:

Pharmacology_of_anabolic_steroids

Abaixo está o resumo:

1: Br J Pharmacol. 2008 Jun;154(3):502-21.

Pharmacology of anabolic steroids.

Kicman AT.

1King's College London, Drug Control Centre, Department of Forensic Science and

Drug Monitoring, London, UK.

Athletes and bodybuilders have recognized for several decades that the use of

anabolic steroids can promote muscle growth and strength but it is only

relatively recently that these agents are being revisited for clinical purposes.

Anabolic steroids are being considered for the treatment of cachexia associated

with chronic disease states, and to address loss of muscle mass in the elderly,

but nevertheless their efficacy still needs to be demonstrated in terms of

improved physical function and quality of life. In sport, these agents are

performance enhancers, this being particularly apparent in women, although there

is a high risk of virilization despite the favourable myotrophic-androgenic

dissociation that many xenobiotic steroids confer. Modulation of androgen

receptor expression appears to be key to partial dissociation, with consideration

of both intracellular steroid metabolism and the topology of the bound androgen

receptor interacting with co-activators. An anticatabolic effect, by interfering

with glucocorticoid receptor expression, remains an attractive hypothesis.

Behavioural changes by non-genomic and genomic pathways probably help motivate

training. Anabolic steroids continue to be the most common adverse finding in

sport and, although apparently rare, designer steroids have been synthesized in

an attempt to circumvent the dope test. Doping with anabolic steroids can result

in damage to health, as recorded meticulously in the former German Democratic

Republic. Even so, it is important not to exaggerate the medical risks associated

with their administration for sporting or bodybuilding purposes but to emphasize

to users that an attitude of personal invulnerability to their adverse effects is

certainly misguided.British Journal of Pharmacology (2008) 154, 502-521;

doi:10.1038/bjp.2008.165.

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